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projects [2020/07/03 11:17]
shyam
projects [2021/06/14 17:35] (current)
shyam [Accrual of patients to Clinical Trials (ACT) network]
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 ===== Projects ===== ===== Projects =====
  
-==== Informatics Core, CTSI ====+==== Biomedical Informatics Core, CTSI ====
 {{ wiki:ctsi.png?300x0}} {{ wiki:ctsi.png?300x0}}
  
-The Informatics Core of the [[http://www.ctsi.pitt.edu/|Clinical and Translational Science Institute (CTSI)]] has established a research data warehouse; developed and deployed user-friendly, web-based informatics tools such as a Cohort Discovery Tool and a Computable Phenotype Library Tool; and is developing a secure data analytic environment.+The Biomedical Informatics Core of the [[http://www.ctsi.pitt.edu/|Clinical and Translational Science Institute (CTSI)]] has established a research data warehouse; developed and deployed user-friendly, web-based informatics tools such as a Cohort Discovery Tool and a Computable Phenotype Library Tool; and is developing a secure data analytic environment.
  
 This work is funded by grant [[https://projectreporter.nih.gov/project_info_description.cfm?aid=9260460|UL1 TR001857]] from NCATS, NIH. This work is funded by grant [[https://projectreporter.nih.gov/project_info_description.cfm?aid=9260460|UL1 TR001857]] from NCATS, NIH.
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 {{ wiki:act.png?200x0}} {{ wiki:act.png?200x0}}
  
-The [[https://www.act-network.org/|Accrual of patients to Clinical Trials (ACT) network]] is a nationwide network of sites that share EHR data to significantly increase participant accrual to the nation’s highest priority clinical trials. It is funded by NCATS' Clinical and Translational Science Awards (CTSA) program that supports efforts to solve system-wide translational research problems to improve the success of U.S. clinical trials. The ACT network is built on existing platforms (i2b2/SHRINE) to create a federated network with common standards, data terminology and shared resources. The ACT investigators are focused on 1) data harmonization across EHR platforms, 2) technical needs assessment and implementation, 3) regulatory approaches to ensure compliance with protocols for data access and participant contact, and 4) governance development to establish proper agreements among institutions. More information is available at [[https://ncats.nih.gov/pubs/features/ctsa-act|NCATS]].+The [[https://www.actnetwork.us/|Accrual of patients to Clinical Trials (ACT) network]] is a nationwide network of sites that share EHR data to significantly increase participant accrual to the nation’s highest priority clinical trials. It is funded by NCATS' Clinical and Translational Science Awards (CTSA) program that supports efforts to solve system-wide translational research problems to improve the success of U.S. clinical trials. The ACT network is built on existing platforms (i2b2/SHRINE) to create a federated network with common standards, data terminology and shared resources. The ACT investigators are focused on 1) data harmonization across EHR platforms, 2) technical needs assessment and implementation, 3) regulatory approaches to ensure compliance with protocols for data access and participant contact, and 4) governance development to establish proper agreements among institutions. More information is available at [[https://ncats.nih.gov/pubs/features/ctsa-act|NCATS]].
  
 This work is funded by grant [[https://projectreporter.nih.gov/project_info_description.cfm?aid=9339795|UL1 TR001857-01S1]] from NCATS, NIH. This work is funded by grant [[https://projectreporter.nih.gov/project_info_description.cfm?aid=9339795|UL1 TR001857-01S1]] from NCATS, NIH.
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-==== Genomics Research and Innovation Network (GRIN) ====+==== Genomic Information Commons (GIC) ====
  
-Genomics Research and Innovation Network (GRIN) is a federated network that is developing two portals for researchers: (A) Prep-to- research portal. Investigators can execute genotype, phenotype, or combined genotype/phenotype queries, and receive aggregate results in real time; and (B) Study portal. With proper approvals, patient-level data are readily transferred to a cloud-hosted environment.+The [[https://www.genomicinformationcommons.org/|Genomic Information Commons (GIC)]] is a federated network that is developing two portals for researchers: (A) Prep-to- research portal. Investigators can execute genotype, phenotype, or combined genotype/phenotype queries, and receive aggregate results in real time; and (B) Study portal. With proper approvals, patient-level data are readily transferred to a cloud-hosted environment.
  
 This work is funded by a [[https://projectreporter.nih.gov/project_info_description.cfm?aid=9818382|U01 grant]] from the NCATS, NIH. This work is funded by a [[https://projectreporter.nih.gov/project_info_description.cfm?aid=9818382|U01 grant]] from the NCATS, NIH.
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 This work is funded by grant [[https://projectreporter.nih.gov/project_info_description.cfm?aid=8931767|U24 OH010873]] from NIOSH, NIH. This work is funded by grant [[https://projectreporter.nih.gov/project_info_description.cfm?aid=8931767|U24 OH010873]] from NIOSH, NIH.
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-==== The TIES Cancer Research Network (TCRN) ==== 
-{{ wiki:tcrn.png?200x0}} 
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-The [[http://ties.dbmi.pitt.edu/|Text Information Extraction System (TIES) Cancer Research Network]]  is a federated network of clinical reports and biospecimen registry to support and facilitate basic science, clinical, and translational research in cancer. TIES uses a sophisticated concept based search to retrieve pathology and radiology reports containing concepts of interest.  Plans include enabling virtual slides and tissue microarray creation. The current participants in the network are University of Pittsburgh, University of Pennsylvania, Augusta University, Roswell Park Cancer Institute, Thomas Jefferson University and Stony Brook University.  
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-This work is funded by grant [[https://projectreporter.nih.gov/project_info_description.cfm?aid=9324915|U24 CA180921]] from NCI, NIH. 
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-==== The Pittsburgh Genome Resource Repository (PGRR) ==== 
-{{ wiki:pgrr_transparent.png?250x0}} 
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-The [[http://www.pgrr.pitt.edu/|Pittsburgh Genome Resource Repository (PGRR)]] provides data management and computing infrastructure to support investigation using The Cancer Genome Atlas (TCGA). TCGA is a “comprehensive and coordinated effort to accelerate the understanding of the molecular basis of cancer through the application of genome analysis technologies, including large-scale genome sequencing”, and is funded by the National Cancer Institute. PGRR processes data and metadata available from TCGA to provide a Pitt-specific ‘snapshot’ of the data and tools for use of this data in a secured environment. 
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-This work is funded by the [[http://www.ipm.pitt.edu//|Institute for Personalized Medicine (IPM)]] and the [[https://upci.upmc.edu/|University of Pittsburgh Cancer Institute (UPCI)]].